Human CD8+ T cell blasts are more sensitive than CD4+ T cell blasts to regulation by APO2L/TRAIL

Killing by Activated Syngeneic NK Cells Stress Renders T Cell Blasts Sensitive to

Lipopolysaccharide Blasts Reactive to T

B lymphocytes can be induced to divide and form Ig-secreting clones either by Tcell help or by mitogens (1, 2). About one in three splenic lymphocytes respond to Bcell mitogens, and such activation is polyclonal: 1 clone in 1,000 produces antibodies against sheep erythrocytes (SRC), 1 1 in 500 against horse erythrocytes (HRC), and 1 in 50 against trinitrophenyl (TNP) (3-5). The presence of mito...

Preselection Thymocytes Are More Sensitive to T Cell Receptor Stimulation Than Mature T Cells

During T cell development, thymocytes which are tolerant to self-peptides but reactive to foreign peptides are selected. The current model for thymocyte selection proposes that self-peptide-major histocompatibility complex (MHC) complexes that bind the T cell receptor with low affinity will promote positive selection while those with high affinity will result in negative selection. Upon thymocy...

CD4 T cell-dependent CD8 T cell maturation.

We have investigated the contribution of CD4 T cells to the optimal priming of functionally robust memory CD8 T cell subsets. Intranasal infection of CD4 T cell-deficient (CD4(-/-)) mice with lymphocytic choriomeningitis virus resulted in the elaboration of virus-specific CD8 T cell responses that cleared the infection. However, by comparison with normal mice, the virus-specific CD8 T cells in ...

CD8+ memory T-cell inflation renders compromised CD4+ T-cell-dependent CD8+ T-cell immunity via naïve T-cell anergy

Whether inflation of CD8+ memory T (mT) cells, which is often derived from repeated prime-boost vaccinations or chronic viral infections in the elderly, would affect late CD8+ T-cell immunity is a long-standing paradox. We have previously established an animal model with mT-cell inflation by transferring ConA-stimulated monoclonal CD8+ T cells derived from Ova-specific T-cell-receptor transgeni...